Pros
As a serial entrepreneur, I was skeptical of joining a large web services company. Surely, I thought, they couldn't feel like a startup, or innovate as well. Boy was I wrong. Akamai is simply amazing. This is one of the only places you will ever work where the CEO on down will understand the most complex ideas you have...not just as business people, but as scientists. Sure, Akamai is a bit 'tougher' than places like Google that give free lunch, but at the same time, you won't find the kind of innovative grit Akamai has either. This is a Fortune 500 company that has a healthy chip on its shoulder, and doesn't believe its own success. Cautious, smart, and immensely supportive...I have encountered nothing but extraordinary people. It has been a joy to work here!
Cons
Some of the remote offices over-compensate, and try to inject themselves into projects they aren't involved in for the glory. The Israel office in particular seems to suffer from this.